Perfusi

Real-Time Tissue Insight

Objective perfusion insights for better surgical decisions

Real-time tissue perfusion monitoring powered by ultrafast Doppler ultrasound. Perfusi shows surgeons whether tissue is receiving the blood it needs, while there is still time to act.

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Firstpurpose-built platform for direct tissue perfusion insight

55first-in-human clinical measurements across multiple organs

2patents with broad coverage

50Mperfusion-relevant procedures each year

Perfusi user interface shown on the intraoperative console. Illustrative visualization; not patient data.

The clinical need

Perfusion determines whether tissue survives

Tissue may look healthy while its blood supply is already compromised.

Even when every technical step of an operation succeeds, inadequate perfusion can still lead to irreversible injury. Today this vital surgical parameter is largely unavailable to surgeons, so decisions are made under uncertainty.

Perfusion deficit goes undetected
Decision comes late or relies on indirect signs
Tissue damage and surgical complications
Reoperation, ICU stay and readmission
Irreversible damage and mortality

One missed perfusion deficit can trigger a cascade of complications and costs.

Blood flow

Doppler and flow meters

Often vessel-specific.

Oxygenation

Regional oximetry

Measures oxygenation, not perfusion.

Tracer passage

ICG fluorescence

Requires dye and provides a time-point view.

Temperature

Thermal imaging

Infers perfusion from surface temperature.

Is the tissue adequately perfused?

Current technologies provide pieces of the answer. Perfusi provides tissue-level insight.

Technology

From raw signal to an actionable surgical insight

A software-based platform built on ultrasound, delivering real-time, objective insight into tissue perfusion at the point of surgery.

01
Acquire
Ultrafast Doppler data from the surgical field.
02
Isolate
Microvascular flow signal from the ultrasound data.
03
Quantify
Relative perfusion change against baseline.
04
Display
Perfusion map, trend and alert for the surgeon.

Proprietary UPDI processing converts ultrasound data into spatial perfusion maps and quantitative relative parameters.

A complete intraoperative ultrasound system

Direct-contact probeSterile and single-use

Placed directly in the surgical field.

Acquisition platformHigh-frame-rate Doppler

Acquires the Doppler data for perfusion analysis.

UPDI processingMicrovascular flow isolation

Turns raw ultrasound into perfusion information.

Surgeon displayQuantitative parameters

Maps, trends and alerts that are clear at a glance.

See the changeUnderstand the significanceAct in time

Clinical evidence

First-in-human evidence captured dynamic perfusion changes

In first-in-human measurements, Perfusi followed perfusion through baseline, occlusion and release as it happened.

Three microvascular perfusion maps of the same tissue: baseline (1–30 s), occlusion (31–60 s) with markedly reduced flow, and release (61–90 s) with flow restored

Hemodynamic time series: relative intensity falls from about 100% to about 40% during occlusion and overshoots to about 160% on release

Baseline 1–30 s · Occlusion 31–60 s · Release 61–90 s. Depth and width in mm.

Published in Nature’s Scientific Reports
Ischemia, collateral flow and reperfusion captured as they occurred
Clinically relevant changes identified beyond conventional assessment

Where we start

Neurosurgery first. A minute matters.

Brain tissue is highly vulnerable to ischemia. Our first customers are high-acuity neurosurgical centers in the US and Europe.

48%Up to 48% complication rate
NowImmediate decision relevance in the operating room
DirectDirect access to the surgical field

From neurosurgery, Perfusi extends into general surgery and other perfusion-critical procedures.

Illustration of a branching vessel network glowing red and orange, with one circled region where flow has faded — Illustration: perfused vessel network with an under-perfused region

Team

Clinical practice, ultrasound technology and medical-device experience

Perfusi was founded by a multidisciplinary team spanning clinical practice, ultrasound technology, and medical-device development and commercialization.

Co-founder & CEO

Pim Polak, MBA

MedTech strategy, financing and commercialization.

COO

Jessica Weiss, MBA

Medical-device operations and regulatory execution.

Co-founder & CMO

Dr. Dara Niknejad

Microvascular neurosurgery and clinical translation.

Co-founder & CTO

Prof. Massimo Mischi, PhD

Biomedical signal processing and ultrasound technology.

Contact

See the change. Understand the significance. Act in time.

We are working with surgeons, hospitals, industry partners and investors to bring objective perfusion insight into the operating room. We would be glad to hear from you.

Pim Polak CEO, Perfusi

pim@perfusi.com